Title: Diterpenes isolated from Croton zambesicus inhibit KCl-induced contraction
Authors: Baccelli, C ×
Block, S
Van Holle, B
Schanck, A
Chapon, D
Tinant, B
Van Meervelt, Luc
Morel, N
Quetin-Leclercq, J #
Issue Date: Jan-2005
Publisher: Georg thieme verlag kg
Series Title: Planta medica vol:71 issue:11 pages:1036-1039
Abstract: A mixture of two new diterpenes was isolated from a dichloromethane extract of Croton zambesicus: ent-18-hydroxytrachyloban-3 beta-ol (1) and ent-18-hydroxyisopimara-7,15-diene-3 beta-ol (2). The two compounds crystallised together and were separated after derivatisation of the pimarane derivative with osmium tetroxide. The structure of 1 was elucidated by 1D- and 2D-NMR analysis and by X-ray diffraction of a crystal containing both compounds while 2 was only identified by crystallographic data. As this plant is widely used in African folk medicine against hypertension, we have analysed the vasorelaxant activity of the isolated molecules. The mixture of the two compounds inhibited the KCl-induced contraction of male Wistar rat aorta (IC50 = 1 mu g/mL), while the purified trachylobane (compound 1) and the bydroxylated pimarane showed a lower activity than the mixture.
ISSN: 0032-0943
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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