Title: Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels
Authors: Schulz, Joachim G
Ceulemans, Helga
Caussinus, Emmanuel
Baietti, Maria Francesca
Affolter, Markus
Hassan, Bassem
David, Guido # ×
Issue Date: Oct-2011
Publisher: Published for EMBO by Oxford University Press
Series Title: EMBO Reports vol:12 issue:10 pages:1039-1046
Article number: 10.1038/embor.2011.153
Abstract: Here we identify a new role for Syndecan (Sdc), the only transmembrane heparan sulphate proteoglycan in Drosophila, in tracheal development. Sdc is required cell autonomously for efficient directed migration and fusion of dorsal branch cells, but not for dorsal branch formation per se. The cytoplasmic domain of Sdc is dispensable, indicating that Sdc does not transduce a signal by itself. Although the branch-specific phenotype of sdc mutants resembles those seen in the absence of Slit/Robo2 signalling, genetic interaction experiments indicate that Sdc also helps to suppress Slit/Robo2 signalling. We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion.
ISSN: 1469-221X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Neuronal Differentiation
Laboratory of Glycobiology and Developmental Genetics (-)
Department of Human Genetics - miscellaneous
Laboratory for Mechanisms of Cell Transformation (VIB-KU Leuven Centre for Cancer Biology)
× corresponding author
# (joint) last author

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