Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Orthopedics, HIP FRACTURE RISK, FALL PREVENTION, SECONDARY HYPERPARATHYROIDISM, MUSCLE STRENGTH, BONE TURNOVER, WOMEN, METAANALYSIS, CHOLECALCIFEROL, AGE, DETERMINANTS, 1103 Clinical Sciences, 3202 Clinical sciences

Abstract:

Calcium and vitamin D supplements reverse secondary hyperparathyroidism and are widely prescribed to prevent osteoporotic fractures, with proven antifracture efficacy when targeted to individuals with documented insufficiencies. Men who should particularly be considered for calcium and vitamin D supplements include elderly or institutionalized individuals, patients with documented osteoporosis on antiresorptive or anabolic medication, and individuals receiving glucocorticoids. Benefits are most apparent when a daily dose of 1000-1200 mg calcium is complemented with 800 IU vitamin D. Compliance is the key to optimizing clinical efficacy. While (conventionally dosed) vitamin D has not been associated with safety concerns, recent meta-analytic data have provided evidence to suggest that calcium supplements (without coadministered vitamin D) may potentially be associated with cardiovascular risks.