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Title: Evolution of exercise capacity with age in patients with atrial switch repair for transposition of the great arteries
Authors: Buys, Roselien
Budts, Werner
Reybrouck, Tony
Gewillig, Marc
Delecluse, Christophe
Vanhees, Luc #
Issue Date: Sep-2011
Publisher: Oxford University Press
Host Document: European Heart Journal vol:32 issue:suppl 1 pages:1032
Conference: ESC congress edition:2011 location:Paris date:27-31 August 2011
Abstract: Purpose
Results of cardiopulmonary exercise testing in patients with atrial switch repair for transposition of the great arteries show a significantly reduced exercise capacity. Our aim is to investigate the evolution of this reduced exercise capacity.

Methods
45 patients (30 male, 15 female) with atrial switch repair for transposition of the great arteries performed 159 cardiopulmonary exercise tests until exhaustion (3.,53±0.66 tests per patient) with an interval of at least 1 year. Mean age at first test was 19.6±7.34 years old. Time between the first and the last exercise test was 6.37 ± 1.44 years (range 3 to 9 years). Peak VO2 and VO2 at anaerobic threshold were measured and expressed as a percentage of normal values according to age and gender. Mean rate of change was calculated for each patient by linear regression analysis.

Results
Mean percentages of peak VO2 and anaerobic threshold were significantly lower than a healthy population (p<0.0001). Mean peak VO2 at the first exercise test was 68.4±14.1% and averaged 62.1±13.5% at the last test. Mean anaerobic threshold at the first exercise test was 72.7±17.2%, and 62.3±16.9% at the last test. Differences between first and last exercise tests were not significant by paired t-test. Mean rate of change was -1.34±3.22% per year for peak VO2 and -1.51±3.62% per year for anaerobic threshold, which is significantly different from the healthy reference population (p=0.008 and p=0.015 respectively).

Conclusions
Patients who underwent atrial switch repair for transposition of the great arteries have a reduced exercise capacity, as expressed by peak VO2 and anaerobic threshold, and this exercise capacity declines faster with age compared to a healthy population.
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Research Group for Cardiovascular and Respiratory Rehabilitation
Cardiology
Cardiovascular Developmental Biology
Exercise Physiology Research Group
# (joint) last author

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