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Title: Co-inheritance of haemoglobin A2’ and beta-thalassaemia in cis
Authors: Vermeersch, Pieter ×
Philippe, M
Goossens, Willy #
Issue Date: Aug-2008
Publisher: Wiley-Blackwell Publishing Ltd.
Series Title: International Journal of Laboratory Hematology vol:30 pages:334-338
Abstract: HbA2' is a haematologically silent delta chain variant that elutes in the S-region on high performance liquid chromatography. The major clinical significance of HbA2' is that failure to detect it might lead to failure to recognize beta-thalassaemia minor. Co-inheritance of HbA2' and beta-thalassaemia in cis has been described only once in a family from Suriname. We describe a new case of co-inheritance in cis of HbA2' and beta-thalassaemia in a family from Ghanaian origin with a HbA2' of more than 3%. Molecular investigation revealed the same mutations as in the family from Suriname, suggesting a common origin of both families.
ISSN: 1751-5521
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical Bacteriology and Mycology
Cardiology
× corresponding author
# (joint) last author

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