Title: Yeast as a model system to study tau biology
Authors: De Vos, Ann
Anandhakumar, Jayamani
Van den Brande, Jeff
Verduyckt, Mathias
Franssens, Vanessa
Winderickx, Joris
Swinnen, Erwin # ×
Issue Date: 2011
Series Title: International journal of Alzheimer's disease vol:2011 pages:428970
Abstract: Hyperphosphorylated and aggregated human protein tau constitutes a hallmark of a multitude of neurodegenerative diseases called tauopathies, exemplified by Alzheimer's disease. In spite of an enormous amount of research performed on tau biology, several crucial questions concerning the mechanisms of tau toxicity remain unanswered. In this paper we will highlight some of the processes involved in tau biology and pathology, focusing on tau phosphorylation and the interplay with oxidative stress. In addition, we will introduce the development of a human tau-expressing yeast model, and discuss some crucial results obtained in this model, highlighting its potential in the elucidation of cellular processes leading to tau toxicity.
ISSN: 2090-0252
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
Laboratory for Functional Biology (-)
× corresponding author
# (joint) last author

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