Switching antidepressant class does not improve response or remission in treatment-resistant depression
Souery, Daniel × Serretti, Alessandro Calati, Raffaella Oswald, Pierre Massat, Isabelle Konstantinidis, Anastasios Linotte, Sylvie Bollen, Jos Demyttenaere, Koen Kasper, Siegfried Lecrubier, Yves Montgomery, Stuart Zohar, Joseph Mendlewicz, Julien #
Lippincott Williams & Wilkins
Journal of Clinical Psychopharmacology vol:31 issue:4 pages:512-6
The management of treatment-resistant depression is a much debated issue. In particular, the evidence supporting the commonly suggested sequential use of antidepressants from 2 different pharmacological classes is weak. This retrospective study was undertaken to investigate whether there is a better response in nonresponders switched to a different class of antidepressants (across-class) compared with nonresponders switched to an antidepressant from the same class (within-class).