Title: Non-channel functions of connexins in cell growth and cell death
Authors: Vinken, Mathieu
Decrock, Elke
Leybaert, Luc
Bultynck, Geert
Himpens, Bernard
Vanhaecke, Tamara
Rogiers, Vera # ×
Issue Date: Aug-2012
Publisher: Elsevier
Series Title: Biochimica et Biophysica Acta. Biomembranes vol:1818 issue:8 pages:2002-8
Abstract: Cellular communication mediated by gap junction channels and hemichannels, both composed of connexin proteins, constitutes two acknowledged regulatory platforms in the accomplishment of tissue homeostasis. In recent years, an abundance of reports has been published indicating functions for connexin proteins in the control of the cellular life cycle that occur independently of their channel activities. This has yet been most exemplified in the context of cell growth and cell death, and is therefore as such addressed in the current paper. Specific attention is hereby paid to the molecular mechanisms that underpin the cellular non-channel roles of connexin proteins, namely the alteration of the expression of tissue homeostasis determinants and the physical interaction with cell growth and cell death regulators. This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and functions.
ISSN: 0005-2736
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular and Cellular Signaling
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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