Title: Poly(2-acrylamido-2-methyl-1-propanamide) (PAMPA): A neutral, water-soluble, synthetic polymer with double-stranded helix conformation
Authors: Wang, Jing ×
Meersman, Filip
Esnouf, Robert
Froeyen, Mathy
Busson, Roger
Heremans, Karel
Herdewijn, Piet #
Issue Date: 2001
Publisher: Wiley-v c h verlag gmbh
Series Title: Helvetica Chimica Acta vol:84 issue:8 pages:2398-2408
Abstract: A new synthetic polymer, poly(2-acrylamido-2-methyl-1-propanamide) (PAMPA), is described. It combines the structural features of poly(leucine) and poly(glutamine), its molecular weight averages 42000 D, and it contains ca. 270 residues. A C-13-NMR-tacticity study indicates that it consists of a mixture of syndiotactic (38%), heterotactic (48%), and isotactic (17%) polymer. PAMPA has a tendency to self-organize into a coiled-coil double-stranded helix structure in aqueous solution, as determined by Fourier-transform. infrared spectroscopy (FT-IR). Molecular modeling of PAMPA shows that the helix formation is driven by repeated intramolecular H-bonds between nearest-neighbor amide groups, and that the structure is further stabilized by hydrophobic interactions between the two lateral Me groups, PAMPA has a neutral structure, is highly water-soluble, and demonstrates temperature stability.
ISSN: 0018-019X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Production Engineering, Machine Design and Automation (PMA) Section
Hypertension and Cardiovascular Epidemiology
Molecular Imaging and Photonics
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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