Title: Carbocyclic 5 '-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity
Authors: Zimmermann, Sarah C ×
Sadler, Joshua M
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Seley-Radtke, Katherine L #
Issue Date: Jul-2011
Publisher: Royal soc chemistry
Series Title: Medchemcomm vol:2 issue:7 pages:650-654
Abstract: A series of 5'-nor carbocyclic "reverse" flexible nucleosides or "fleximers" have been designed wherein the nucleobase scaffold resembles a "split" purine as well as a substituted pyrimidine. This modification was employed to explore recognition by both purine and pyrimidine metabolizing enzymes. The synthesis of the carbocyclic fleximers and the results of their preliminary biological screening are described herein.
ISSN: 2040-2503
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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