Title: Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia
Authors: Steinberg, Stacy ×
de Jong, Simone
Irish Schizophrenia Genomics Consortium
Andreassen, Ole A
Werge, Thomas
Børglum, Anders D
Mors, Ole
Mortensen, Preben B
Gustafsson, Omar
Costas, Javier
Pietiläinen, Olli P H
Demontis, Ditte
Papiol, Sergi
Huttenlocher, Johanna
Mattheisen, Manuel
Breuer, René
Vassos, Evangelos
Giegling, Ina
Fraser, Gillian
Walker, Nicholas
Tuulio-Henriksson, Annamari
Suvisaari, Jaana
Lönnqvist, Jouko
Paunio, Tiina
Agartz, Ingrid
Melle, Ingrid
Djurovic, Srdjan
Strengman, Eric
Jürgens, Gesche
Glenthøj, Birte
Terenius, Lars
Hougaard, David M
Orntoft, Torben
Wiuf, Carsten
Didriksen, Michael
Hollegaard, Mads V
Nordentoft, Merete
van Winkel, Ruud
Kenis, Gunter
Abramova, Lilia
Kaleda, Vasily
Arrojo, Manuel
Sanjuán, Julio
Arango, Celso
Sperling, Swetlana
Rossner, Moritz
Ribolsi, Michele
Magni, Valentina
Siracusano, Alberto
Christiansen, Claus
Kiemeney, Lambertus A
Veldink, Jan
van den Berg, Leonard
Ingason, Andres
Muglia, Pierandrea
Murray, Robin
Nöthen, Markus M
Sigurdsson, Engilbert
Petursson, Hannes
Thorsteinsdottir, Unnur
Kong, Augustine
Rubino, I Alex
De Hert, Marc
Réthelyi, János M
Bitter, István
Jönsson, Erik G
Golimbet, Vera
Carracedo, Angel
Ehrenreich, Hannelore
Craddock, Nick
Owen, Michael J
O'Donovan, Michael C
Wellcome Trust Case Control Consortium
Ruggeri, Mirella
Tosato, Sarah
Peltonen, Leena
Ophoff, Roel A
Collier, David A
St Clair, David
Rietschel, Marcella
Cichon, Sven
Stefansson, Hreinn
Rujescu, Dan
Stefansson, Kari #
Issue Date: Oct-2011
Publisher: IRL Press
Series Title: Human Molecular Genetics vol:20 issue:20 pages:4076-4081
Abstract: Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association (GWA) study and meta-analysis (totalling 7,946 cases and 19,036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10,260 cases and 23,500 controls). In addition to previously-reported alleles in the major histocompatibility complex (MHC) region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) (OR = 1.09, P = 1.9 x 10(-9)), and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously-described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 x 10(-9)).
ISSN: 0964-6906
Publication status: published
KU Leuven publication type: IT
Appears in Collections:University Centre Sint Jozef (-)
Research Group Psychiatry
× corresponding author
# (joint) last author

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