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Title: Modularity in developmental biology and artificial organs: a missing concept in tissue engineering
Authors: Lenas, Petros ×
Luyten, Frank
Doblare, Manuel
Nicodemou-Lena, Eleni
Lanzara, Andreina Elena #
Issue Date: Jun-2011
Publisher: Blackwell Science
Series Title: Artificial Organs vol:35 issue:6 pages:656-62
Article number: 10.1111/j.1525-1594.2010.01135.x
Abstract: Tissue engineering is reviving itself, adopting the concept of biomimetics of in vivo tissue development. A basic concept of developmental biology is the modularity of the tissue architecture according to which intermediates in tissue development constitute semiautonomous entities. Both engineering and nature have chosen the modular architecture to optimize the product or organism development and evolution. Bioartificial tissues do not have a modular architecture. On the contrary, artificial organs of modular architecture have been already developed in the field of artificial organs. Therefore the conceptual support of tissue engineering by the field of artificial organs becomes critical in its new endeavor of recapitulating in vitro the in vivo tissue development.
URI: 
ISSN: 0160-564X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Rheumatology Section (-)
× corresponding author
# (joint) last author

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