Estimating the magnitude of genetic factors by calculating the genetic relative risk of stroke in first-ever lacunar stroke patients
Knottnerus, Iris L H × Gielen, Marij Lodder, Jan Rouhl, Rob P W Staals, Julie Vlietinck, Robert van Oostenbrugge, Robert J #
Public Library of Sciene
PLoS One vol:6 issue:6 pages:e21439
Positive family history of stroke is an independent risk factor for lacunar stroke. However, the magnitude of familial aggregation of a certain disease is better evaluated by the genetic relative risk. This is calculated by dividing the prevalence of specific disease in family members of patients by the prevalence of this disease in the general population. In a cohort of lacunar stroke patients, who were subtyped clinically and radiologically, we determined the genetic relative risk of stroke.