Title: Case Report of a Poorly Differentiated Uterine Tumour with t(10;17) Translocation and Neuroectodermal Phenotype
Authors: Amant, Frédéric ×
Tousseyn, Thomas
Coenegrachts, Lieve
Decloedt, Jan
Moerman, Philippe
Debiec-Rychter, Maria #
Issue Date: Jun-2011
Publisher: Potamitis Press
Series Title: Anticancer Research vol:31 issue:6 pages:2367-2371
Abstract: Endometrial stromal sarcoma (ESS) with primitive neuroectodermal differentiation is a very uncommon entity. Such a case presenting as stage IIIc (International Federation of Gynaecology and Obstetrics (FIGO) 2010) disease in a 51-year-old female is described. Microscopy suggested a small blue round cell tumour. Cytogenetic and multicolour fluorescent in situ hybridisation (M-FISH) analysis revealed a complex karyotype with the presence of unbalanced t(10;17)(q22;p13) translocation, indicating ESS. Peripheral Ewing´s sarcoma was excluded based on FISH and RT-PCR fusion transcripts analysis. After surgical staging, the patient received bleomycin-etoposide-cisplatin combination chemotherapy. A detailed analysis of the histopathology and genetic findings forms the basis of this report.
ISSN: 0250-7005
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Gynaecological Oncology
Translational Cell & Tissue Research
Section Woman - Miscellaneous (-)
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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