Title: Emerging immunosuppressive drugs in kidney transplantation
Authors: Metalidis, Christoph ×
Kuypers, Dirk #
Issue Date: May-2011
Publisher: Bentham Science Publishers Ltd.
Series Title: Current Clinical Pharmacology vol:6 issue:2 pages:130-6
Abstract: Calcineurin inhibitors (CNI), a cornerstone of current immunosuppressive therapy, have important cardiovascular and oncogenic side effects and CNI nephrotoxicity contributes to the multifactorial process called "chronic allograft dysfunction", the leading cause of chronic allograft failure among kidney transplant recipients. New drugs, with a different mechanism of action, are being developed focusing on a better balance between drug efficacy and toxicity. These novel compounds interfere with either T-cell mediated or antibody-mediated rejection. In this review, we report on the mechanism of action, pharmacokinetics and preliminary results of clinical trials of these promising new immunosuppressive drugs.
ISSN: 1574-8847
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Nephrology
× corresponding author
# (joint) last author

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