Author:

Keywords:

SISTA, Science & Technology, Physical Sciences, Physics, Multidisciplinary, Physics, Mathematical modeling, Excitable and oscillatory dynamics, Synchronization, Spiral waves, TISSUE MODEL, MYOCYTES, DYNAMICS, MUSCLE, 01 Mathematical Sciences, 02 Physical Sciences, Fluids & Plasmas, 49 Mathematical sciences, 51 Physical sciences

Abstract:

A simple computationally efficient model which is capable of replicating the basic features of cardiac cell action potential is proposed. The model is a four-dimensional map and demonstrates good correspondence with real cardiac cells. Various regimes of cardiac activity, which can be reproduced by the proposed model, are shown. Bifurcation mechanisms of these regimes transitions are explained using phase space analysis. The dynamics of 1D and 2D lattices of coupled maps which model the behavior of electrically connected cells is discussed in the context of synchronization theory. © 2011 Elsevier B.V. All rights reserved.