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Title: Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila
Authors: Nicola├», Laura
Ramaekers, Ariane
Raemaekers, Tim
Drozdzecki, Andrzej
Mauss, Alex S
Yan, Jiekun
Landgraf, Matthias
Annaert, Wim
Hassan, Bassem # ×
Issue Date: Nov-2010
Publisher: National Academy of Sciences
Series Title: Proceedings of the National Academy of Sciences of the United States of America vol:107 issue:47 pages:20553-20558
Abstract: In recent years, Drosophila melanogaster has emerged as a powerful model for neuronal circuit development, pathology, and function. A major impediment to these studies has been the lack of a genetically encoded, specific, universal, and phenotypically neutral marker of the somatodendritic compartment. We have developed such a marker and show that it is effective and specific in all neuronal populations tested in the peripheral and central nervous system. The marker, which we name DenMark (Dendritic Marker), is a hybrid protein of the mouse protein ICAM5/Telencephalin and the red fluorescent protein mCherry. We show that DenMark is a powerful tool for revealing novel aspects of the neuroanatomy of developing dendrites, identifying previously unknown dendritic arbors, and elucidating neuronal connectivity.
ISSN: 0027-8424
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biomedical Sciences Group Management - miscellaneous
Laboratory of Membrane Trafficking
Laboratory of Neurogenetics
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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