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Title: Nonlinear-optical activity and biomolecular chirality
Authors: Verbiest, Thierry ×
Kauranen, M
Persoons, Andre
Ikonen, M
Kurkela, J
Lemmetyinen, H #
Issue Date: Jan-1994
Publisher: Amer chemical soc
Series Title: Journal of the American Chemical Society vol:116 issue:20 pages:9203-9205
Abstract: Circular-difference response of second-harmonic generation from chiral surfaces is shown to be a sensitive probe of chiral biological samples. The sensitivity of this nonlinear effect is several orders of magnitude higher than that of linear circular dichroism and is demonstrated using samples of bacteriorhodopsin. This nonlinear optical activity probes molecular chirality on a more general level than linear techniques. Surface specifity of the novel approach can be of considerable importance in the study of biological membranes. Hence, this process has the potential of becoming a new chiro-optical tool in the fields of analytical (bio)chemistry, surface chemistry, and cell biology.
ISSN: 0002-7863
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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