Title: Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene
Authors: Kornev, Alexey B ×
Peregudov, Alexander S
Martynenko, Vyacheslav M
Balzarini, Jan
Hoorelbeke, Bart
Troshin, Pavel A #
Issue Date: Aug-2011
Publisher: Royal Society of Chemistry
Series Title: Chemical Communications vol:47 issue:29 pages:8298-300
Abstract: We report here a facile preparation of highly water-soluble derivatives C(70)[p-C(6)H(4)(CH(2))(n)COOH](8) (n = 2, 3) starting from readily available chlorinated [70]fullerene precursors C(70)Cl(8) and C(70)Cl(10). The synthesized fullerene derivatives showed pronounced antiviral activity in vitro, particularly against human immunodeficiency virus (HIV) and influenza A virus (subtypes H1N1 and H3N2).
ISSN: 1359-7345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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