Title: Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease
Authors: Lagoja, Irene ×
Pannecouque, Christophe
Griffioen, Gerard
Wera, Stefaan
Rojasdelaparra, Veronica Maria
Van Aerschot, Arthur #
Issue Date: Aug-2011
Publisher: Elsevier
Series Title: European Journal of Pharmaceutical Sciences vol:43 issue:5 pages:386-392
Abstract: A novel series of 2-aminothiazoles with strong protection in an Alzheimer's disease (AD) model comprising tau-induced neuronal toxicity is disclosed. These derivatives can be synthesized in one-pot and a small SAR of the substitution within these series afforded several compounds that counteracted tau-induced cell toxicity at nanomolar concentrations. These congeners therefore have strong potential as possible treatment for Alzheimer's disease and other related tauopathies.
ISSN: 0928-0987
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2011093.pdf Published 317KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science