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Title: Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues
Authors: Ali, Mohamed A ×
Ismail, Rusli
Choon, Tan S
Yoon, Yeong K
Wei, Ang C
Pandian, Suresh
Samy, Jeyabalan G
De Clercq, Erik
Pannecouque, Christophe #
Issue Date: May-2011
Series Title: Acta Poloniae Pharmaceutica vol:68 issue:3 pages:343-348
Abstract: A series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues were synthesized by the reaction of 5,6-dimethoxy-2-[(E)-1-phenylmethylidene]-1-indanone with hydroxylamine hydrochloride. The title compounds were tested for their in vitro anti-HIV activity. Among the compounds, (4g) showed a promising anti-HIV activity in the in vitro testing against IIIB and ROD strains. The IC50 of both IIIB and ROD were found to be 9.05 microM and > 125 microM, respectively.
ISSN: 0001-6837
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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