Title: Molecular Implication of PP2A and Pin1 in the Alzheimer's Disease Specific Hyperphosphorylation of Tau
Authors: Landrieu, Isabelle ×
Smet-Nocca, Caroline
Amniai, Laziza
Louis, Justin Vijay
Wieruszeski, Jean-Michel
Goris, Jozef
Janssens, Veerle
Lippens, Guy #
Issue Date: Jun-2011
Publisher: Public Library of Sciene
Series Title: PLoS One vol:6 issue:6
Article number: e21521
Abstract: Tau phosphorylation and dephosphorylation regulate in a poorly understood manner its physiological role of microtubule stabilization, and equally its integration in Alzheimer disease (AD) related fibrils. A specific phospho-pattern will result from the balance between kinases and phosphatases. The heterotrimeric Protein Phosphatase type 2A encompassing regulatory subunit PR55/Bα (PP2A(T55α)) is a major Tau phosphatase in vivo, which contributes to its final phosphorylation state. We use NMR spectroscopy to determine the dephosphorylation rates of phospho-Tau by this major brain phosphatase, and present site-specific and kinetic data for the individual sites including the pS202/pT205 AT8 and pT231 AT180 phospho-epitopes.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Protein Phosphorylation and Proteomics
Laboratory of Experimental Genetics and Transgenesis (-)
× corresponding author
# (joint) last author

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