Title: VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1
Authors: Ruiz de Almodovar, Carmen
Fabre, Pierre J
Knevels, Ellen
Coulon, Cathy
Segura, Inmaculade
Haddick, Patrick C G
Aerts, Liesbeth
Delattin, Nicolas
Strasser, Geraldine
Oh, Won-Jong
Lange, Christian
Vinckier, Stefan
Haigh, Jody
Fouquet, Coralie
Alitalo, Kari
Castellani, Valerie
Tessier-Lavigne, Marc
Chedotal, Alain
Charron, Frederic
Carmeliet, Peter # ×
Issue Date: Jun-2011
Publisher: Cell Press
Series Title: Neuron vol:70 issue:5 pages:966-978
Abstract: Growing axons are guided to their targets by attractive and repulsive cues. In the developing spinal cord, Netrin-1 and Shh guide commissural axons toward the midline. However, the combined inhibition of their activity in commissural axon turning assays does not completely abrogate turning toward floor plate tissue, suggesting that additional guidance cues are present. Here we show that the prototypic angiogenic factor VEGF is secreted by the floor plate and is a chemoattractant for commissural axons in vitro and in vivo. Inactivation of Vegf in the floor plate or of its receptor Flk1 in commissural neurons causes axon guidance defects, whereas Flk1 blockade inhibits turning of axons to VEGF in vitro. Similar to Shh and Netrin-1, VEGF-mediated commissural axon guidance requires the activity of Src family kinases. Our results identify VEGF and Flk1 as a novel ligand/receptor pair controlling commissural axon guidance.
ISSN: 0896-6273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven Center for Brain & Disease Research)
Centre of Microbial and Plant Genetics
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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