Title: Relevance of mast cell-nerve interactions in intestinal nociception
Authors: van Diest, Sophie A ×
Stanisor, Oana I
Boeckxstaens, Guy
de Jonge, Wouter J
van den Wijngaard, René M #
Issue Date: Jan-2012
Publisher: Elsevier
Series Title: Biochimica et Biophysica Acta. Molecular Basis of Disease vol:1822 issue:1 pages:74-84
Abstract: Cross-talk between the immune- and nervous-system is considered an important biological process in health and disease. Because mast cells are often strategically placed between nerves and surrounding (immune)-cells they may function as important intermediate cells. This review summarizes the current knowledge on bidirectional interaction between mast cells and nerves and its possible relevance in (inflammation-induced) increased nociception. Our main focus is on mast cell mediators involved in sensitization of TRP channels, thereby contributing to nociception, as well as neuron-released neuropeptides and their effects on mast cell activation. Furthermore we discuss mechanisms involved in physical mast cell-nerve interactions. This article is part of a Special Issue entitled: Mast cells in inflammation.
ISSN: 0925-4439
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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