Relevance of mast cell-nerve interactions in intestinal nociception
van Diest, Sophie A × Stanisor, Oana I Boeckxstaens, Guy de Jonge, Wouter J van den Wijngaard, René M #
Biochimica et Biophysica Acta. Molecular Basis of Disease vol:1822 issue:1 pages:74-84
Cross-talk between the immune- and nervous-system is considered an important biological process in health and disease. Because mast cells are often strategically placed between nerves and surrounding (immune)-cells they may function as important intermediate cells. This review summarizes the current knowledge on bidirectional interaction between mast cells and nerves and its possible relevance in (inflammation-induced) increased nociception. Our main focus is on mast cell mediators involved in sensitization of TRP channels, thereby contributing to nociception, as well as neuron-released neuropeptides and their effects on mast cell activation. Furthermore we discuss mechanisms involved in physical mast cell-nerve interactions. This article is part of a Special Issue entitled: Mast cells in inflammation.