C-16-methyl corticosteroids are far less allergenic than the non-methylated molecules
Baeck, Marie × Chemelle, Julie-Anne Rasse, Catherine Terreux, Raphael Goossens, An #
Contact Dermatitis vol:64 issue:6 pages:305-312
Background. It has been confirmed that binding to amino acids in skin proteins takes place at C-21 after oxidation of the corticosteroid molecule, which gives to the constituents of the D-ring an essential role in cross-reactivity patterns. In 2000, Matura et al. subdivided the corticosteroid esters of the D-group into two subgroups: D1, the 'stable' esters; and D2, the 'labile' esters. Recent data have indicated that non-methylated corticosteroids selectively react with arginine to form stable cyclic adducts, which are probably implicated in sensitization to corticosteroids.