Title: C-16-methyl corticosteroids are far less allergenic than the non-methylated molecules
Authors: Baeck, Marie ×
Chemelle, Julie-Anne
Rasse, Catherine
Terreux, Raphael
Goossens, An #
Issue Date: 2011
Publisher: Munksgaard
Series Title: Contact Dermatitis vol:64 issue:6 pages:305-312
Abstract: Background. It has been confirmed that binding to amino acids in skin proteins takes place at C-21 after oxidation of the corticosteroid molecule, which gives to the constituents of the D-ring an essential role in cross-reactivity patterns. In 2000, Matura et al. subdivided the corticosteroid esters of the D-group into two subgroups: D1, the 'stable' esters; and D2, the 'labile' esters. Recent data have indicated that non-methylated corticosteroids selectively react with arginine to form stable cyclic adducts, which are probably implicated in sensitization to corticosteroids.
ISSN: 0105-1873
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Dermatoimmunology (+)
× corresponding author
# (joint) last author

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