Title: Expanding the substitution pattern of 2(1H)-pyrazinones via Suzuki and Heck reactions
Authors: Azzam, R
De Borggraeve, Wim
Compernolle, Frans ×
Hoornaert, GJ #
Issue Date: Jan-2005
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:61 issue:16 pages:3953-3962
Abstract: Various 3,5-dichloropyrazinones were substituted at the C-3 position with (hetero)aryl, alkyl and alkenyl groups by means of Suzuki and Heck reactions. The methodology could be extended to reactions on the far less reactive C-5 position by transhalogenation of the 5-Cl substituent to a 5-Br or a 5-I group prior to performing the cross-coupling. (c) 2005 Elsevier Ltd. All rights reserved.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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