Author:

Keywords:

Antigens, CD, Antigens, CD14, Bone Marrow Cells, Chemokine CXCL12, Diabetic Retinopathy, Endothelial Cells, Endothelium, Vascular, Epiretinal Membrane, Glycoproteins, Humans, Immunoenzyme Techniques, Peptides, Receptors, CXCR4, Retinal Neovascularization, Retinal Vessels, Stem Cells, Vascular Endothelial Growth Factor Receptor-2, Science & Technology, Life Sciences & Biomedicine, Ophthalmology, diabetic retinopathy, endothelial progenitor cells, monocytes, stromal cell-derived factor-1, vasculogenesis, HUMAN CD34(+) CELLS, PROGENITOR CELLS, DIFFERENTIATION, SDF-1, RECRUITMENT, POPULATION, ADHESION, VEGFR-2, GROWTH, CD133, AC133 Antigen, Lipopolysaccharide Receptors, 1103 Clinical Sciences, 1109 Neurosciences, 1113 Opthalmology and Optometry, Ophthalmology & Optometry, 3212 Ophthalmology and optometry

Abstract:

The role of vasculogenesis, recruitment and differentiation of circulating bone-marrow-derived endothelial precursor cells into mature endothelium in proliferative diabetic retinopathy (PDR) remains undefined. We investigated the presence of bone-marrow-derived endothelial precursor cells and the expression of the chemotactic pathway SDF-1 ⁄CXCL12)CXCR4 in PDR epiretinal membranes.