Title: Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation
Authors: Krysko, Dmitri V ×
Agostinis, Patrizia
Krysko, Olga
GARG, Abhishek
Bachert, Claus
Lambrecht, Bart N
Vandenabeele, Peter #
Issue Date: Apr-2011
Publisher: Elsevier Science Ltd.
Series Title: Trends in Immunology vol:32 issue:4 pages:157-164
Abstract: Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These molecules are recognized by the innate immune system by pattern recognition receptors - the same receptors that detect pathogen-associated molecular patterns, thus revealing similarities between pathogen-induced and non-infectious inflammatory responses. Many DAMPs are derived from the plasma membrane, nucleus, endoplasmic reticulum and cytosol. Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondrial DAMPs and discuss their contribution to inflammation and development of human pathologies.
ISSN: 1471-4906
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Cell Death Research & Therapy
× corresponding author
# (joint) last author

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