Title: Predictive impact of DNA repair functionality on clinical outcome of advanced sarcoma patients treated with trabectedin: A retrospective multicentric study
Authors: Sch√∂ffski, Patrick ×
Taron, M.
Jimeno, J.
Grosso, F.
Sanfilipio, R.
Casali, P.G.
Le Cesne, A
Jones, R.L.
Blay, J.Y.
Poveda, A.
Maki, R.G.
Nieto, A.
Tercero, J.C
Rosen, R. #
Issue Date: May-2011
Publisher: Pergamon
Series Title: European Journal of Cancer vol:47 issue:7 pages:1006-1012
Abstract: Aim: Trabectedin sensitivity is increased in cells with functional nucleotide excision DNA repair, whereas efficient homologous recombination repair leads to resistance. On this basis, a retrospective study of mRNA expression of BRCA1 (breast cancer susceptibility 1 gene), XPG (Xeroderma pigmentosum group G gene) and ERCC1 (excision-repair cross complementing group 1 gene) in tumour samples from sarcoma patients treated with trabectedin was conducted, to correlate DNA repair profiles with patient outcome.
ISSN: 0959-8049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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