Title: Management of menopausal symptoms in breast cancer patients
Authors: Loibl, S ×
Lintermans, Anneleen
Dieudonné, Anne-Sophie
Neven, Patrick #
Issue Date: Feb-2011
Publisher: Elsevier/North-Holland Biomedical Press
Series Title: Maturitas vol:68 issue:2 pages:148-154
Abstract: In breast cancer patients, menopausal symptoms such as hot flashes, urogenital problems, musculoskeletal symptoms and cognitive dysfunction are common, regardless of age at diagnosis. They affect quality of life and systemic therapy will worsen this. Endocrine and/or chemotherapy may induce temporary or permanent ovarian failure and can exacerbate these symptoms. Hormone therapy (HT) has been studied in breast cancer survivors, but safety has been questioned. The HABITS trial investigating estrogen-based HT, as well as the LIBERATE trial investigating tibolone, found a reduction in disease-free survival for those treated. Alternative strategies are needed, as menopause symptoms may reduce compliance with breast cancer treatments. This article reviews recently published strategies to tackle menopausal problems in breast cancer patients. Antidepressants may help with hot flashes. Acupuncture and hypnosis can also be used but the evidence is conflicting. For urogenital problems vaginal moisturizers or topical estrogens can be employed. A musculoskeletal syndrome induced by aromatase inhibitors (AIs) is frequently encountered and currently there are no effective treatment strategies. Bisphosphonates reduce AI-induced bone resorption and can also increase disease-free and overall survival. Standard-dose endocrine and chemotherapy are associated with a decline in cognitive function.
ISSN: 0378-5122
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Section Woman - Miscellaneous (-)
× corresponding author
# (joint) last author

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