Title: cis-fused hexahydro-4aH-indeno[1,2-b]pyridines: transformation of bridgehead ester group and conversion to tricyclic analogues of NK-1 and dopamine receptor ligands
Authors: De Wit, Tom ×
Van Emelen, K
Maertens, Faye
Hoornaert, GJ
Compernolle, Frans #
Issue Date: Jan-2001
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron letters vol:42 issue:29 pages:4919-4922
Abstract: The: bridgehead ester group of cis-fused methyl 2-oxo-9b-phenyl-1,2,3,4,5,9b-hexahydro-4aH-indeno[1,2-b]pyridine-4a-carboxylates obtained via an intramolecular Ritter reaction, was transformed into acid, alcohol, aldehyde and amine groups. Further elaboration afforded conformationally constrained tricyclic analogues of NK-1 antagonists and a bicyclic dopamine receptor ligand. (C) 2001 Elsevier Science Ltd. All right reserved.
ISSN: 0040-4039
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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