Title: Synthesis of o-2- and n-3-(2-phosphonomethoxy)ethyl derivatives of 6-phenyl- and 6-pyridinyl-5-azacytosine
Authors: Otmar, Miroslav ×
Dracinsky, Martin
Krecmerova, Marcela
Balzarini, Jan
Andrei, Graciela
Snoeck, Robert #
Issue Date: Apr-2011
Publisher: Sendai Institute of Heterocyclic Chemistry
Series Title: Heterocycles vol:83 issue:4 pages:797-813
Abstract: A series of hydrolytically stable O-2- and N-3-(2-phosphonomethoxy)ethyl (PME) derivatives of 6-phenyl, pyridin-2, -3 and -4-yl-5-azacytosines was prepared by their alkylation with diisopropyl (2-chloroethoxy)methylphosphonate followed by the deprotection. No antitumor or antiviral activity was found except for 6-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine (13d) which exhibited slight activity against feline herpesvirus in CrFK cell cultures with IC50 = 6.7 mu g/mL.
ISSN: 0385-5414
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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