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Title: Evaluation of Ordered Mesoporous Silica as a Carrier for Poorly Soluble Drugs: Influence of Pressure on the Structure and Drug Release
Authors: Vialpando, Monica
Aerts, Alexander
Persoons, Jeroen
Martens, Johan
Van den Mooter, Guy # ×
Issue Date: Aug-2011
Publisher: American Chemical Society and American Pharmaceutical Association
Series Title: Journal of Pharmaceutical Sciences vol:100 issue:8 pages:3411-3420
Abstract: Ordered mesoporous silica (OMS) materials are considered a promising drug delivery system for the dissolution enhancement of poorly soluble compounds. The purpose of the present work was to determine structural and behavioral changes of compressed OMS material necessary for the development of an immediate-release oral-dosage formulation. Two types of OMS materials (SBA-15 and COK-12) were subjected to pressures both in and beyond the tabletting region and characterized by nitrogen physisorption, scanning and transmission electron microscopy, small-angle X-ray scattering, and differential scanning calorimetry. Itraconazole was used as the poorly soluble model drug and the release process with respect to pressure was determined in vitro. The resulting decreased drug release due to increased pressure was recovered by incorporating a plastically deforming material such as microcrystalline cellulose in combination with croscarmellose sodium. These findings further elucidate the understanding of their structural behavior for the advancement as a drug delivery carrier. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:3411-3420, 2011
ISSN: 0022-3549
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Surface Chemistry and Catalysis
Drug Delivery and Disposition
× corresponding author
# (joint) last author

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