Title: Protein unfolding, amyloid fibril formation and configurational energy landscapes under high pressure conditions
Authors: Meersman, Filip ×
Dobson, Christopher M
Heremans, Karel #
Issue Date: Jan-2006
Publisher: Royal soc chemistry
Series Title: Chemical society reviews vol:35 issue:10 pages:908-917
Abstract: High hydrostatic pressure induces conformational changes in proteins ranging from compression of the molecules to loss of native structure. In this tutorial review we describe how the interplay between the volume change and the compressibility leads to pressure-induced unfolding of proteins and dissociation of amyloid fibrils. We also discuss the effect of pressure on protein folding and free energy landscapes. From a molecular viewpoint, pressure effects can be rationalised in terms of packing and hydration of proteins.
ISSN: 0306-0012
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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