Title: Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy
Authors: Altin, John A ×
Tian, Lei
Liston, Adrian
Bertram, Edward M
Goodnow, Christopher C
Cook, Matthew C #
Issue Date: May-2011
Publisher: Elsevier
Series Title: Journal of Allergy and Clinical Immunology vol:127 issue:5 pages:1277-U296
Abstract: Background: Allergy, the most common disease of immune dysregulation, has a substantial genetic component that is poorly understood. Although complete disruption of T-cell receptor (TCR) signaling causes profound immunodeficiency, little is known about the consequences of inherited genetic variants that cause partial quantitative decreases in particular TCR-signaling pathways, despite their potential to dysregulate immune responses and cause immunopathology.
ISSN: 0091-6749
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Genetics of Autoimmunity
× corresponding author
# (joint) last author

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