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Title: A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
Authors: Mavrakis, Konstantinos J ×
Van Der Meulen, Joni
Wolfe, Andrew L
Liu, Xiaoping
Mets, Evelien
Taghon, Tom
Khan, Aly A
Setti, Manu
Rondou, Pieter
Vandenberghe, Peter
Delabesse, Eric
Benoit, Yves
Socci, Nicholas B
Leslie, Christina S
Van Vlierberghe, Pieter
Speleman, Frank
Wendel, Hans-Guido #
Issue Date: Jun-2011
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:43 issue:7 pages:673-678
Abstract: The importance of individual microRNAs (miRNAs) has been established in specific cancers. However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of any specific cancer is lacking. Here we show that in T-cell acute lymphoblastic leukemia (T-ALL), a small set of miRNAs is responsible for the cooperative suppression of several tumor suppressor genes. Cross-comparison of miRNA expression profiles in human T-ALL with the results of an unbiased miRNA library screen allowed us to identify five miRNAs (miR-19b, miR-20a, miR-26a, miR-92 and miR-223) that are capable of promoting T-ALL development in a mouse model and which account for the majority of miRNA expression in human T-ALL. Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, including IKAROS (also known as IKZF1), PTEN, BIM, PHF6, NF1 and FBXW7. Thus, a comprehensive and unbiased analysis of miRNA action in T-ALL reveals a striking pattern of miRNA-tumor suppressor gene interactions in this cancer.
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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