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Title: Gray-scale and color Doppler ultrasound characteristics of endometrial cancer in relation to stage, grade and tumor size
Authors: Epstein, Elisabeth ×
Van Holsbeke, Caroline
Mascilini, Floriana
Måsbäck, Anna
Kannisto, Päivi
Ameye, Lieveke
Fischerova, Daniela
Zannoni, Gianfranco F
Vellone, Valerio
Timmerman, Dirk
Testa, Antonia Carla #
Issue Date: Nov-2011
Publisher: Blackwell Science
Series Title: Ultrasound in Obstetrics & Gynecology vol:38 issue:5 pages:586-593
Article number: 10.1002/uog.9038
Abstract: AIM: To describe the gray-scale and vascular characteristic of endometrial cancer in relation to stage, grade, and size using 2D/3D transvaginal ultrasound. METHODS: Prospective multicenter study including 144 women with endometrial cancer undergoing transvaginal ultrasound prior to surgery. The sonographic characteristics assessed were: echogenicity, endometrial/myometrial border, fibroids, vascular pattern, color score, and tumor/uterus antero-posterior (AP) ratio. Histological assessment of tumor stage, grade, type, and growth pattern, was performed. RESULTS: Hyper- or isoechoic tumors were more often seen in stage IA, whereas mixed or hypoechoic tumors were more often found in ≥ stage IB (p = 0.003). Hyperechoic tumors were more common in grade 1-2 tumors, p = 0.02, and tumors with a tumor/uterine AP ratio of < 50% of the uterus p=0.002, whereas non-hyperechoic appearance was more commonly found in grade 3 tumors and tumors with a tumor/uterine AP ratio ≥ 50% of the uterus. Multiple global vessels were more often seen in ≥ stage IB tumors than IA tumors p=0.02, in grade 3 tumors than in grade 1 and 2 tumors p=0.02, and in tumors with a tumor/uterine AP ratio ≥ 50%, p<0.001. A moderate/high color score was significantly more common in tumors of higher stage (p=0.03) and greater size (p=0.001). CONCLUSION: The sonographic appearance of endometrial cancer is significantly associated with tumor stage, grade and size. More advanced tumors often have a mixed/hypoechoic echogenicity, a higher color score and multiple globally entering vessels, whereas less advanced tumors are more often hyperechoic, and have no or low color score. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
ISSN: 0960-7692
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Imaging Section (-)
Interdepartmental Platform Hospital Care
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
× corresponding author
# (joint) last author

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