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Title: Outcome of pregnancy in women with inflammatory bowel disease treated with antitumor necrosis factor therapy
Authors: Schnitzler, Fabian ×
Fidder, Herma
Ferrante, Marc
Ballet, Vera
Noman, Maja
Van Assche, Gert
Spitz, Bernard
Hoffman, Ilse
Van Steen, Kristel
Vermeire, Severine
Rutgeerts, Paul #
Issue Date: Sep-2011
Publisher: John Wiley & Sons
Series Title: Inflammatory Bowel Diseases vol:17 issue:9 pages:1846-1854
Article number: 10.1002/ibd.21583
Abstract: BACKGROUND:: Infliximab (IFX) and adalimumab (ADA) are attractive treatment options in patients with inflammatory bowel disease (IBD) also during pregnancy but there is still limited data on the benefit/risk profile of IFX and ADA during pregnancy. METHODS:: This observational study assessed pregnancy outcomes in 212 women with IBD under antitumor necrosis factor alpha (TNF) treatment at our IBD unit. Pregnancy outcomes in 42 pregnancies with direct exposure to anti-TNF treatment (35 IFX, 7 ADA) were compared with that in 23 pregnancies prior to IBD diagnosis, 78 pregnancies before start of IFX, 53 pregnancies with indirect exposure to IFX, and 56 matched pregnancies in healthy women. RESULTS:: Thirty-two of the 42 pregnancies ended in live births with a median gestational age of 38 weeks (interquartile range [IQR] 37-39). There were seven premature deliveries, six children had low birth weight, and there was one stillbirth. One boy weighed 1640 g delivered at week 33, died at age of 13 days because of necrotizing enterocolitis. A total of eight abortions (one patient wish) occurred in seven women. Trisomy 18 was diagnosed in one fetus of a mother with CD at age 37 under ADA treatment (40 mg weekly) and pregnancy was terminated. Pregnancy outcomes after direct exposure to anti-TNF treatment were not different from those in pregnancies before anti-TNF treatment or with indirect exposure to anti-TNF treatment but outcomes were worse than in pregnancies before IBD diagnosis. CONCLUSIONS:: Direct exposure to anti-TNF treatment during pregnancy was not related to a higher incidence of adverse pregnancy outcomes than IBD overall. (Inflamm Bowel Dis 2011;).
URI: 
ISSN: 1078-0998
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pathophysiology of Pregnancy Section (-)
Department of Human Genetics - miscellaneous
Translational Research in GastroIntestinal Disorders
Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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