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Title: The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development
Authors: Goossens, Tim ×
Kang, Yuan Y
Wuytens, Gunther
Zimmermann, Pascale
Callaerts-Vegh, Zsuzsanna
Pollarolo, Giulia
Islam, Rafique
Hortsch, Michael
Callaerts, Patrick #
Issue Date: Apr-2011
Publisher: Company of Biologists
Series Title: Development vol:138 issue:8 pages:1595-1605
Abstract: The spatiotemporal integration of adhesion and signaling during neuritogenesis is an important prerequisite for the establishment of neuronal networks in the developing brain. In this study, we describe the role of the L1-type CAM Neuroglian protein (NRG) in different steps of Drosophila mushroom body (MB) neuron axonogenesis. Selective axon bundling in the peduncle requires both the extracellular and the intracellular domain of NRG. We uncover a novel role for the ZO-1 homolog Polychaetoid (PYD) in axon branching and in sister branch outgrowth and guidance downstream of the neuron-specific isoform NRG-180. Furthermore, genetic analyses show that the role of NRG in different aspects of MB axonal development not only involves PYD, but also TRIO, SEMA-1A and RAC1.
ISSN: 0950-1991
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
Intellectual Property
Department of Human Genetics - miscellaneous
Laboratory of Neuronal Differentiation
× corresponding author
# (joint) last author

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