The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors
Di Modugno, Francesca × Mottolese, Marcella Di Benedetto, Anna Conidi, Andrea Novelli, Flavia Perracchio, Letizia Venturo, Irene Botti, Claudio Jager, Elke Santoni, Angela Natali, Pier Giorgio Nisticò, Paola #
Association for Cancer Research
Clinical Cancer Research vol:12 issue:5 pages:1470-8
hMena (ENAH), a cytoskeleton regulatory protein involved in the regulation of cell motility and adhesion, is overexpressed in breast cancer. The aim of this study was to define at what stage of breast carcinogenesis hMena is overexpressed and to correlate hMena overexpression with established prognostic factors in breast cancer, focusing on human epidermal growth factor receptor-2 (HER-2).