Title: Nfix regulates fetal-specific transcription in developing skeletal muscle
Authors: Messina, Graziella ×
Biressi, Stefano
Monteverde, Stefania
Magli, Alessandro
Cassano, Marco
Perani, Laura
Roncaglia, Elena
Tagliafico, Enrico
Starnes, Linda
Campbell, Christine E
Grossi, Milena
Goldhamer, David J
Gronostajski, Richard M
Cossu, Giulio #
Issue Date: Feb-2010
Publisher: MIT Press
Series Title: Cell vol:140 issue:4 pages:554-66
Abstract: Skeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that involve different cell populations and expression of different genes. We show here that the transcription factor nuclear factor one X (Nfix), whose expression is activated by Pax7 in fetal muscle, in turn activates the transcription of fetal specific genes such as MCK and beta-enolase while repressing embryonic genes such as slow myosin. In the case of the MCK promoter, Nfix forms a complex with PKC theta that binds, phosphorylates, and activates MEF2A. Premature expression of Nfix activates fetal and suppresses embryonic genes in embryonic muscle, whereas muscle-specific ablation of Nfix prevents fetal and maintains embryonic gene expression in the fetus. Therefore, Nfix acts as a transcriptional switch from embryonic to fetal myogenesis.
ISSN: 0092-8674
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Embryo and Stemcells (-)
× corresponding author
# (joint) last author

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