Gene expression profiling of human angiotropic primary melanoma: Selection of 15 differentially expressed genes potentially involved in extravascular migratory metastasis
Lugassy, Claire × Lazar, Vladimir Dessen, Philippe van den Oord, Joost Winnepenninckx, Véronique Spatz, Alan Bagot, Martine Bensussan, Armand Janin, Anne Eggermont, Alexander M Barnhill, Raymond L #
European Journal of Cancer vol:47 issue:8 pages:1267-1275
Angiotropism and extravascular migratory metastasis (EVMM) are an important alternative means of melanoma spread. In EVMM, melanoma cells migrate along the external surfaces of vascular channels to distant sites and demonstrate microscopic angiotropism, i.e. melanoma cells arrayed along the external surfaces of vascular endothelium. Pertinent to EVMM are the origin of melanocytes from the neural crest (NC) and strong analogies of EVMM with NC cell migration. Our aim is to elucidate the molecular mechanisms underlying angiotropism and EVMM.