Title: Gene expression profiling of human angiotropic primary melanoma: Selection of 15 differentially expressed genes potentially involved in extravascular migratory metastasis
Authors: Lugassy, Claire ×
Lazar, Vladimir
Dessen, Philippe
van den Oord, Joost
Winnepenninckx, Véronique
Spatz, Alan
Bagot, Martine
Bensussan, Armand
Janin, Anne
Eggermont, Alexander M
Barnhill, Raymond L #
Issue Date: May-2011
Publisher: Pergamon
Series Title: European Journal of Cancer vol:47 issue:8 pages:1267-1275
Abstract: Angiotropism and extravascular migratory metastasis (EVMM) are an important alternative means of melanoma spread. In EVMM, melanoma cells migrate along the external surfaces of vascular channels to distant sites and demonstrate microscopic angiotropism, i.e. melanoma cells arrayed along the external surfaces of vascular endothelium. Pertinent to EVMM are the origin of melanocytes from the neural crest (NC) and strong analogies of EVMM with NC cell migration. Our aim is to elucidate the molecular mechanisms underlying angiotropism and EVMM.
ISSN: 0959-8049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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