Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
Ibáñez, Lourdes × Lopez-Bermejo, Abel Diaz, Marta Marcos, Maria Victoria de Zegher, Francis #
American Society for Reproductive Medicine
Fertility and Sterility vol:95 issue:2 pages:727-30
To study the effects of early metformin treatment on menarche, height, and polycystic ovary syndrome (PCOS) markers. Low-birthweight (LBW) girls with precocious pubarche (PP) are at risk for an early menarche (<12 years), an adult stature below target level, and PCOS. Hyperinsulinemic insulin resistance is thought to be a key factor.