Title: Limited stage I disease is not necessarily indicative of an excellent prognosis in childhood anaplastic large cell lymphoma (ALCL)
Authors: Attarbaschi, Andishe ×
Mann, Georg
Rosolen, Angelo
Williams, Denise
Uyttebroeck, Anne
Marky, Ildiko
Lamant, Laurence
Horibe, Keizo
Wrobel, Grazyna
Beishuizen, Auke
Wössmann, Wilhelm
Reiter, Alfred
Mauguen, Audrey
Le Deley, Marie-Cecile
Brugières, Laurence #
Issue Date: Mar-2011
Publisher: W.B. Saunders
Series Title: Blood
Abstract: Data on incidence, characteristics and prognosis in stage I childhood anaplastic large cell lymphoma (ALCL) are scarce. Out of 463 patients (pts.) enrolled into the international trial ALCL99, 36 (8%) cases had stage I disease and were treated with a prephase followed by either 3 chemotherapy courses in case of initial complete resection (6 pts.) or otherwise by 6 courses (30 pts.). Disease localization was peripheral lymph nodes in 26, soft tissue mass in 8, solitary bone and bronchial disease in one patient each. Of the 6 patients with complete resection none suffered from relapse while of the 30 patients 9 (30%) relapsed including in all cases a new site of disease involvement and 3 of 5 ALK- patients. In summary, the failure rate for non-completely resected disease was similar to patients with stage II and III/IV disease. Whether ALK-negativity contributed to this moderate outcome has to be proven prospectively. This study was registered at as NCT00006455.
ISSN: 0006-4971
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pediatric Hematology & Oncology Section (-)
Section Child - Miscellaneous (-)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science