Title: Galectin-1 and immunotherapy for brain cancer
Authors: Verschuere, Tina ×
De Vleeschouwer, Steven
Lefranc, Florence
Kiss, Robert
Van Gool, Stefaan #
Issue Date: Apr-2011
Publisher: Expert Reviews Ltd.
Series Title: Expert Review of Neurotherapeutics vol:11 issue:4 pages:533-543
Abstract: The prognosis of patients diagnosed with high-grade glioma continues to be dismal in spite of multimodal treatment. Active specific immunotherapy by means of dendritic cell vaccination is considered to be a new promising concept that aims at generating an anti-tumoral immune response. However, it is now widely accepted that the success of immunotherapeutic strategies to promote tumor regression will rely not only on enhancing the effector arm of the immune response but also on downregulation of the counteracting tolerogenic signals. In this article, we summarize evidence that galectin-1, an evolutionarily conserved glycan-binding protein that is abundantly expressed in high-grade glioma, is an important player in glioma-mediated immune escape.
ISSN: 1473-7175
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Brain & Metabolism Section (-)
Laboratory of Clinical Immunology
Research Group Experimental Neurosurgery and Neuroanatomy
Pediatric Hematology & Oncology Section (-)
Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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