Title: Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease
Authors: Brouwers, Nicolas ×
Sleegers, K
Engelborghs, S
Maurer-Stroh, S
Gijselinck, I
van der Zee, J
Pickut, B A
Van den Broeck, M
Mattheijssens, M
Peeters, K
Schymkowitz, Joost
Rousseau, Frederic
Martin, J-J
Cruts, M
De Deyn, P P
Van Broeckhoven, C #
Issue Date: Aug-2008
Publisher: Advanstar Communications
Series Title: Neurology vol:71 issue:9 pages:656-664
Abstract: Loss-of-function mutations in the progranulin gene (PGRN) were identified in frontotemporal lobar degeneration (FTLD) with ubiquitin-immunoreactive neuronal inclusions (FTLD-U). We assessed whether PGRN also contributes to genetic risk for Alzheimer disease (AD) in an extended Belgian AD patient group (n = 779, onset age 74.7 +/- 8.7 years).
ISSN: 0028-3878
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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