Title: Computational design of peptide ligands
Authors: Vanhee, Peter ×
van der Sloot, Almer M
Verschueren, Erik
Serrano, Luis
Rousseau, Frederic
Schymkowitz, Joost #
Issue Date: May-2011
Publisher: Elsevier Ltd., Trends Journals
Series Title: Trends in Biotechnology vol:29 issue:5 pages:231-239
Abstract: Peptides possess several attractive features when compared to small molecule and protein therapeutics, such as high structural compatibility with target proteins, the ability to disrupt protein-protein interfaces, and small size. Efficient design of high-affinity peptide ligands via rational methods has been a major obstacle to the development of this potential drug class. However, structural insights into the architecture of protein-peptide interfaces have recently culminated in several computational approaches for the rational design of peptides that target proteins. These methods provide a valuable alternative to experimental high-resolution structures of target protein-peptide complexes, bringing closer the dream of in silico designed peptides for therapeutic applications.
ISSN: 0167-7799
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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