Title: Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis
Authors: Abu El-Asrar, Ahmed M ×
Struyf, Sofie
Kangave, Dustan
Al-Obeidan, Saleh S
Opdenakker, Ghislain
Geboes, Karel
Van Damme, Jozef #
Issue Date: May-2011
Publisher: Academic Press
Series Title: Clinical Immunology vol:139 issue:2 pages:177-184
Abstract: We assayed aqueous humor (AH) samples from patients with Behçet's disease (BD), Vogt-Koyanagi-Harada (VKH) disease, and HLA-B27-associated uveitis and control patients for the proinflammatory cytokines IL-15, IL-17, interferon-γ and tumor necrosis factor-α and the immunosuppressive cytokine IL-10. Cytokine levels were significantly higher in the three disease groups than in controls. In patients with similar disease activity, levels of IL-15 and IFN-γ were significantly higher in BD patients than in VKH and HLA-B27-associated uveitis groups. Logistic regression identified a significant negative correlation between BD and high levels of IL-10 and a significant positive correlation between VKH disease and high levels of IL-10. The proinflammatory cytokines versus IL-10 ratios were significantly higher in BD compared with other groups. These data suggest that both T helper (Th) 1 and Th17 cells are involved in endogenous uveitis immunopathogenesis. BD is characterized by extensive Th1 polarization, severe proinflammatory conditions and a low immunosuppressive status.
ISSN: 1521-6616
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
Laboratory of Molecular Immunology (Rega Institute)
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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