Title: Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity
Authors: Singh, Kamaljit ×
Singh, Kawaljit
Wan, Baojie
Franzblau, Scott
Chibale, Kelly
Balzarini, Jan #
Issue Date: Jun-2011
Series Title: European Journal of Medicinal Chemistry vol:46 issue:6 pages:2290-4
Abstract: A series of pyrimidine derivatives bearing amine substituents at C-2 position were obtained from Biginelli 3,4-dihydropyrimidin-2(1H)-ones and the effect of structural variation on anti-TB activity against Mycobacterium tuberculosis H(37)Rv strain and antiviral activity in a series of cell cultures was evaluated. While the compounds were found to possess structure dependent cytostatic activity, these were not found to be efficient inhibitors of M. tuberculosis nor did they inhibit a broad variety of DNA or RNA viruses in cell culture.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2011061.pdf Published 150KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science