Title: Effect of pH and comedication on gastrointestinal absorption of posaconazole: monitoring of intraluminal and plasma drug concentrations
Authors: Walravens, Jeroen * ×
Brouwers, Joachim *
Spriet, Isabel
Tack, Jan
Annaert, Pieter
Augustijns, Patrick #
Issue Date: Nov-2011
Publisher: ADIS Press International
Series Title: Clinical Pharmacokinetics vol:50 issue:11 pages:726-734
Abstract: Posaconazole (Noxafil®) is an extended-spectrum triazole antifungal agent for prevention and treatment of invasive fungal infections. An inadequate dietary intake and abnormal gastric pH levels are common in critically ill patients receiving antifungal treatment with posaconazole, resulting in unpredictable bioavailability and sub-therapeutic plasma concentrations. This study was carried out to elucidate the impact of pH on posaconazole absorption and to explore the underlying mechanisms of enhanced intestinal absorption when coadministering an acidic carbonated beverage. In contrast to previously published studies, in which only plasma concentrations were determined, we also explored the gastric and intestinal behaviour of posaconazole after a single oral dose.
ISSN: 0312-5963
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
Translational Research in GastroIntestinal Disorders
Clinical Pharmacology and Pharmacotherapy
* (joint) first author
× corresponding author
# (joint) last author

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